ABSTRACT
Objective To investigate the long-term toxicity of an Uyhgur medicine, Kursi Kaknaq, on hematological parameters in the rats.Methods A total of 120 healthy Sprague-Dawley rats were randomly divided into the control, low dose (0.32 g/kg? d ), moderate dose (1.6 g/kg? d) and high dose (3.2g/kg? d) Kursi Kaknaq groups.The drug was given orally, 6 days per week for 180 days.The control group was given 0.5% sodium carboxymethyl cellulose suspension. Results No death was recorded in the rats and no obvious toxic events were observed during the experiment. Hematological parameters including RBC, HGB, MCH, MCHC, LYMP%, WBC, and PLT; biochemical parameters including ALT,AST, ALP, GLU, BUN, ALB ,TBIL, Crea, TCHO, TG, and CK; electrolyte time parameters such as K+, Na+, Cl-and prothrombin time(PT) showed statistically significant differences (P <0.05 and P <0.01), but did not show time and dose effect regularity, and no pathological significance.Conclusions No obvious toxic effects on hematological parameters are observed in the SD rats treated with Kursi Kaknaq at doses of 0.32 g, 1.6 g, or 3.2 g (crude drug) /kg? d orally administered for 180 days, indicating that this drug is safe for long-term clinical use.
ABSTRACT
Objective To observe the effect of a Uyghur medicine Munziq Balgam on the mouse model of psoriasis.Methods 130 healthy Kunming mice were used in this study .The mouse model of psoriasis was established by applying 5% propranol hydrochloride emulsion to the mouse ear .The tail and ear skin histology was examined using HE staining, and the serum levels of IL-10, IL-17, IL-23 were measured with ELISA.Results The mice of Munziq Balgam treated groups (2, 4, 8 g/kg) did not show obvious abnormalities of general condition and body weight changes (P >0.05).The 8 g/kg Munziq Balgam treated group showed decreased thymus index (P 0.05). The 2, 4, and 8 g/kg Munziq Balgam treated groups showed promoted formation of epidermis granular layer in the mouse tail skin and improved histology of the ear skin .Conclusions The Uygur medicine Munziq Balgam shows therapeutic effect on experimental mouse models of psoriasis .